During compounding, what is a critical step to ensure safety when handling high-risk level CSPs?

Aseptic manipulation is a critical step when handling high-risk level compounded sterile preparations (CSPs) because it ensures that the products are free from contamination. High-risk level CSPs include those that are made from non-sterile ingredients or that are exposed to environmental conditions that could introduce harmful microorganisms. Proper aseptic techniques involve working in sterile environments, such as a laminar flow hood, using sterile equipment, and maintaining a clean workflow to prevent contamination.

In contrast, using general gloves would not provide sufficient protection against contamination or ensure the sterility of the CSPs being prepared. Similarly, opting for a less accurate scale compromises the precision required in dosing, which is vital for patient safety and the efficacy of the medication. Ignoring expiration dates could also lead to the use of compromised ingredients, which poses significant risks. Overall, aseptic manipulation is paramount for ensuring the safety and effectiveness of high-risk level CSPs.