What is a requirement for hazardous drug preparation in a Sterile Compounding Environment?

In a Sterile Compounding Environment, the requirement for hazardous drug preparation is to maintain negative pressure in the ante room relative to the buffer area. This practice is crucial for ensuring safety and containment of hazardous drugs. Negative pressure means that the air pressure in the ante room is lower than that in the buffer area, which helps to prevent the escape of airborne contaminants from the designated area where hazardous drugs are handled and compounded.

This arrangement protects both the compounding personnel and the environment from potential exposure to hazardous agents. The design and pressure differentials also assist in effectively ventilating and filtering the air, further reducing the risk of contamination and exposure. Proper airflow is essential to the safety protocols in a compounding environment, particularly when dealing with drugs that can be harmful if inhaled or absorbed through the skin.

Other options, such as maintaining positive pressure in the buffer area, are not suitable for hazardous drug preparation because they could potentially allow contaminants to escape into adjacent spaces. A minimum of 15 air changes per hour (ACPH) is indeed important in a sterile environment, but it governs the cleanliness of the environment rather than the pressure differential required specifically for hazardous drug preparation. Lastly, ensuring no physical barriers between areas would contradict the established protocols designed to isolate hazardous