What should be applied inside the Primary Engineering Control (PEC) immediately before initiating compounding?

Before initiating compounding inside the Primary Engineering Control (PEC), the application of 70% Isopropyl Alcohol (IPA) is the recommended practice. This concentration of IPA is effective in ensuring a quick and efficient reduction of microbial load on surfaces, making it suitable for disinfecting the work area just prior to compounding. The 70% formulation works optimally because it allows for prolonged contact time, which enhances its ability to penetrate the cell walls of bacteria and viruses, ensuring effective disinfection.

Using a higher concentration of alcohol, like 100% ethanol, may lead to rapid evaporation, which can decrease efficacy, as the alcohol would not remain in contact with the surface long enough to effectively kill microorganisms. While a sporicidal agent is useful for periodic cleaning to eliminate spores, it is not typically required for routine disinfection just before compounding. Disinfecting wipes can be convenient, but they might not have the same effectiveness as 70% IPA, particularly in terms of contact time and coverage when used on larger surface areas. Thus, 70% IPA is the critically accepted method for ensuring the cleanliness and sterility of the PEC before starting any compounding activities.