Which area should have a greater air change rate, the buffer area or the ante area?

The buffer area should have a greater air change rate because it is the critical space where sterile compounding is performed. This area is required to maintain a controlled environment with low levels of airborne particulate contamination to ensure the safety and efficacy of sterile products. Higher air change rates in the buffer area help to prevent microbial contamination and maintain the required ISO classification for sterile compounding.

In contrast, the ante area, which serves as a transitioning space where personnel don barrier attire and prepare for entry into the buffer area, does not require as stringent levels of control. While the ante area must maintain cleanliness, the lesser air change rate is sufficient for its function because it is not where the actual sterile manipulations take place.

This distinction helps ensure that the environment in the buffer area remains optimal for compounding, thus securing the sterility of the medications being prepared.