Which USP chapter focuses on preventing patient harm from microbial contamination?

Chapter 797 of the USP specifically addresses the practices and requirements for sterile compounding to minimize the risk of microbial contamination, which is critical for ensuring patient safety. This chapter outlines standards for the preparation of compounded sterile products (CSPs), emphasizing the need for appropriate sterility testing, environmental controls, and proper handling techniques to prevent contamination.

Chapter 797 sets forth guidelines regarding the use of primary engineering controls such as laminar airflow hoods and cleanrooms designed to maintain air quality, as well as the appropriate use of personal protective equipment (PPE) when compounding sterile products. These measures are essential for reducing the likelihood of microbial contamination, which can lead to serious patient harm if unaddressed.

The other chapters mentioned, such as Chapter 795, focus on non-sterile compounding, and Chapter 800 addresses hazardous drugs in healthcare settings. While these chapters are relevant to compounding practices, they do not specifically target the prevention of microbial contamination in sterile products, which is the primary concern of Chapter 797. This is why Chapter 797 is the correct choice in relation to preventing patient harm from microbial contamination.